Epilepsy with Myoclonic Atonic Seizures Special Interest Group (SIG)
We aim to further elucidate the natural history of EMAS, investigate the current diagnostic and therapeutic milieu, and move toward discovering, evaluating, and implementing the optimal treatments for this disease. This involves developing a comprehensive prospective registry to eventually identify biomarkers for treatment outcomes and also to establish best practices in the care of this epilepsy.
EMAS SIG Leader: Michael Ciliberto, M.D., University of Iowa
To see what times our Special Interest Group meets, please click here.
Ongoing projects
No trials at this time. We are developing an infrastructure grant to develop a database.
Past projects
Eschbach K, Moss A, Joshi C, Angione K, Smith G, Dempsey A,Juarez-Colunga E, Demarest ST. Diagnosis switching and outcomes in a cohort of patients with potential epilepsy with myoclonic-atonic seizures. Epilepsy Res. 2018 Nov;147:95-101. doi: 10.1016/j.eplepsyres.2018.09.011. Epub 2018 Sep 24. PMID: 30286391; PMCID: PMC6223641.
Diagnosis Switching and Outcomes in a Cohort of Patients with Potential Epilepsy with Myoclonic-Atonic Seizures – PMC (nih.gov)
Nickels K, Thibert R, Rau S, Demarest S, Wirrell E, Kossoff EH, Joshi C, Nangia S, Shellhaas R; Pediatric Epilepsy Research Consortium. How do we diagnose and treat epilepsy with myoclonic-atonic seizures (Doose syndrome)? Results of the Pediatric Epilepsy Research Consortium survey. Epilepsy Res. 2018 Aug;144:14-19. doi: 10.1016/j.eplepsyres.2018.04.010. Epub 2018 Apr 25. PMID: 29729532.
How do we diagnose and treat epilepsy with myoclonic-atonic seizures (Doose syndrome)? Results of the Pediatric Epilepsy Research Consortium survey – PubMed (nih.gov)
Joshi C, Nickels K, Demarest S, Eltze C, Cross JH, Wirrell E. Results of an international Delphi consensus in epilepsy with myoclonic atonic seizures/ Doose syndrome. Seizure. 2021 Feb;85:12-18. doi: 10.1016/j.seizure.2020.11.017. Epub 2020 Dec 28. PMID: 33383403.
Results of an international Delphi consensus in epilepsy with myoclonic atonic seizures/ Doose syndrome – PubMed (nih.gov)
Nickels K, Kossoff EH, Eschbach K, Joshi C. Epilepsy with myoclonic-atonic seizures (Doose syndrome): Clarification of diagnosis and treatment options through a large retrospective multicenter cohort. Epilepsia. 2021 Jan;62(1):120-127. doi: 10.1111/epi.16752. Epub 2020 Nov 14. PMID: 33190223.
Epilepsy with myoclonic-atonic seizures (Doose syndrome): Clarification of diagnosis and treatment options through a large retrospective multicenter cohort – PubMed (nih.gov)
Member meetings
To join a Special Interest Group (SIG), please contact PERC’s Executive Director, Jane McCabe, at jane@perc-epilepsy.org. In order to join PERC, your institution must be a member, which currently involves the signing of a Memo of Understanding and a commitment from each member institution to actively participate in one or more SIGs. PERC’s Special Interest Groups typically meet via Zoom on a regular basis, in addition to meeting in person at national epilepsy conferences.